Other structural MR studies have shown inconsistent results: for example, the observation of Galaburda has been replicated only in 50% of the MRI studies. Anatomical measures of other structures such as the Corpus Callosum have also provided variable results: - Enlarged Splenium
- Shrinkage in the Genu
- Abnormally shaped Isthmus.
A Voxel-Based Morphometry (VBM) study, reported reduced grey matter in:
- Orbital portion of the left Inferior Frontal Gyrus
- Orbital portion of the Superior Temporal Gyrus
- Outside the classical language regions.
The largest clusters were detected in: - Left temporo-Parietal-Occipital region
- Left Inferior Gyri
- Middle Temporal Gyri
- Inferior Frontal Gyri
- Superior Frontal Gyri
- Superior Cerebellar regions bilaterally
No differences in white matter densities were reported, others reported 4 anatomical measures that differentiated phonological dyslexic subjects from reading-disabled and control subjects: - Marked rightward cerebral asymmetry
- Marked leftward asymmetry of the anterior lobe of the cerebellum
- Combined leftward asymmetry of the planum temporale and posterior ascending ramus of the sylvian fissure
- Large duplication of Heschl’s gyrus on the left
Others found significant morphological cerebral alterations in dyslexic children. In areas that showed significant correlations with reading, spelling and language measures:
- Smaller right anterior cerebellar lobes,
- Pars triangularis of the inferior frontal gyrus bilaterally
- Overall brain volume
A recent VBM study, observed significant reductions of grey matter volume in areas of the brain associated with language and reading processing in people with a family history of dyslexia. Significant reductions were located bilaterally in: - Planum temporale
- Inferior temporal cortex
- Cerebellar nuclei
- Left superior and inferior temporal regions
Finally, there is one MRI morphometric study on the cerebellum, found that, although normal controls had a larger right hemispheric cerebellar cortical surface, the cerebellar hemispheres in the dyslexic subjects were symmetric. |